breen lab @ ncsu

Matthew Breen :: PhD :: C.Biol :: FRSB ::

Professor of Genomics and the Oscar J. Fletcher Distinguished Professor of Comparative Oncology Genetics



If you are interested in making a tax deductible donation to support this research please consider visiting the

North Carolina Veterinary Medical Foundation

(mention the "Cancer Genomics Fund")

Thank you.




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Study Participation Information Upadate

The BreenLab at NC State University sends our sincere appreciation to the many people who have submitted valuable specimens from their dogs to be included in our cancer research program. Without these precious samples we would not have been able to perform the research that is now leading to new discoveries that will enhance the lives of dogs, and perhaps people, with several types of cancer.

At this time we have taken the difficult decision to suspend recruitment of new cases so that we can allocate all our time and resources to analyzing the samples that have already been submitted.

We are delighted to report that these studies have already led to the development of the following genetic tests.

AVAILABLE NOW under the CAncer DETection (CADET) brand of Sentinel Biomedical

Detection of canine bladder/prostate cancer

The CADET BRAF Mutation Detection Assay provides a method for early detection, diagnosis and monitoring of canine bladder and prostate cancer – also known as transitional cell carcinoma (TCC) or urothelial carcinoma (UC).

The CADET BRAF Mutation Detection Assay is available in two forms: i) as a diagnostic and monitoring assay through Sentinel Biomedical, for dogs that have symptoms consistent with a bladder/prostate cancer, and ii) as a screening assay through the American Kennel Club, for early detection of TCC/UC in pre-symptomatic dogs of high risk breeds. Both tests are based on the submission of a non-invasive, free-catch urine specimen.

Detection of canine histiocytic malignacies

The CADET HM Assay is a genetic test that aids distinction between histiocytic malignancies and other round cell neoplasms (eg lymphoma, hemangiosarcoma) that may share similar symptoms and histologic appearance. Sample submission is a cytological smear of aspirated cells or a formalin-fixed paraffin-embedded biopsy specimen.

Detection of a BCR-ABL translocation in canine leukemia

The CADET BCR-ABL Assay is a genetic test that identifies the presence of a BCR-ABL fusion in canine leukemias, used by veterinarians to determine the likely efficacy of tyrosine kinase inhibitor based therapy. Sample submission requires heparin blood tube.



For canine lymphoma: a genetic test to predict how long a dog with lymphoma will remain in remission when treated with chemotherapy. Sample submission is a fine needle aspirate, cytology preparation or formalin-fixed paraffin-embedded biopsy specimen of an affected lymph node, acquired prior to any chemotherapy treatment.

For canine melanoma: a genetic test to identify aggressive canine mucosal melanoma. Sample submission is a fine needle aspirate, cytology preparation, or formalin-fixed paraffin-embedded biopsy specimen of an oral mass.






Full mailing address and contact details for further information

Breen Lab
North Carolina State University
College of Veterinary Medicine
CVM Research Building, Room 330
1060 William Moore Drive
NC 27607, USA

Tel: 919-513-1466 Fax: 919-513-7301